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SELENIUM STUDY
Vitamins and minerals have different functions in the body. B-complex vitamins, for example, help release energy from food and iron helps red blood cells transport oxygen. Other minerals, particularly copper, manganese, selenium and zinc are used by the body to make antioxidant enzymes. These enzymes help protect cells from harmful chemicals produced by "oxidative stress."
There is evidence that oxidative stress occurs at increased levels in people with HIV/AIDS, a fact which can further weaken the immune system. It is therefore not surprising that a deficiency in the nutrients needed to make antioxidants can be linked to reduced survival. This is the case in the present study where the risk of dying "associated with a selenium deficiency is 15 times higher than that associated with a low CD4+ cell count."
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Study Details
Researchers enrolled 43 females and 82 males who had as a group an average CD4+ count of 428 cells (27% had less than 200 cells) at the start of the study. Seventy-eight percent of the group were drug-users and were observed by the research team for an average of 3.5 years.
Results
The researchers found that very low levels of certain nutrients--vitamins A, B12, selenium, zinc and protein--were all associated with reduced survival compared to others who did not have such low levels of nutrients. This difference was statistically significant; that is, not likely due to chance alone. In analysing the data the researchers found that a deficiency of selenium was best able to predict survival/death. Few subjects in this study used anti-HIV drugs, but if they did, treatment was AZT alone. Given these facts, it is not surprising that the use of anti-HIV drugs in this study was not associated with a higher chance of survival.
The next step should be to test the impact of supplements of antioxidant nutrients, including selenium, on the immune systems of PHAs. Most supplement regimens use up to 200 microgrammes/day of selenium.
REFERENCES:
1. Taylor EW, Bhat A, Nadimpalli RG, et al. HIV encodes a sequence overlapping env gp41 with highly significant similarity to selenium-dependent glutathione peroxidases. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology 1997;15(5):393-394.
2. Baum MK, Shor-Posner G, Lai S, et al. High risk of HIV-related mortality is associated with selenium deficiency. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology 1997;15(5):370-374.
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