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ANTIOXIDANT ENZYMES
Natural antioxidant enzymes manufactured in the body provide an important defense against free radicals. Glutathione peroxidase, glutathione reductase, catalase and superoxide dismutase are among the most important antioxidant enzymes. The regulatory gene sequence for producing antioxidant enzymes, both constitutively and by induction, is called the Antioxidant Response Element (ARE). The most important transcription factors for regulating and upregulating the ARE are Nuclear Factor Erythroid 2 p-45 related factors 1 and 2 (especially NF-E2-related factor 2, Nrf2). Nrf1 and Nrf2 are phase 2 detoxification enzyme inducers, which means they also induce enzymes which conjugate toxins to increase water solubility and excretion.
Nrf2 also regulates the activity of glutathione-synthesizing enzyme, both under normal conditions (constitutive gene expression) and under conditions of oxidative stress (which induces more gene expression). With age Nrf2 levels can fall by half, resulting in declining levels of glutathione as well as decreased capacity to increase glutathione synthesis in response to oxidative stress. Lipoic acid has been shown to restore Nrf2 activity in the liver of aging rats [PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES (USA); Suh,JH; 101(10):3381-3386 (2004)].
The proinflammatory cytokine Tumor Necrosis Factor-alpha (TNF-alpha) can increase gene expression for synthesis of glutathione, whereas corticosteroids (which suppress both inflammation and immune response) reduce glutathione synthesis [JOURNAL OF BIOLOGICAL CHEMISTRY; Rahman,I; 274(8):5088-5096 (1999)]. The isothiocyanate sulforaphane found in broccoli is a very potent phase 2 enzyme inducer that raises cellular glutathione. Sulforaphane is a potent inducer of the enzyme heme oxygenase which catalyzes the formation of the powerful antioxidant bilirubin from heme (of hemoglobin) [FOOD AND CHEMICAL TOXICOLOGY; Fahey,JW; 37:973-979 (1999)].
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For the past three years our research team at Sharp Labs Inc. has been watching the outcome of many placebos for various tests on many so claimed "Super Antioxidants". We know now so much more about what vitamins and minerals work as true antioxidants for our immune system and what vitamin co factors work well together with regard to antioxidant performance. We are proud to offer our best antioxidant formula yet. "Cell Protect" is a super antioxidant formula that is dynamic and keeps changing with modern research results. We keep our formula top notch for only the best in aiding your diet for immune system boosting power.
For instance did you know?
1)Vitamin A has been ruled out as a super antioxidant in high doses and can actually be harmful and increase
cancer risk especially in smokers. Vitamin A in small doses such as in "Cell Protect" although works well with Vitamin E and other vitamins.
2)Flax Seed extracts have had good results while being tested for antioxidant performance.
3)Garlic is quickly becoming our most exciting antioxidant ingredient yet amd tests have shown that garlic
is all good and has no bad side effects. Garlic powder extract will be released in our newest "Cell Protect"
formula being released shortly.
4)Vitamin C can be used in large amounts and not be harmful but our bodies will only process set amounts for what it needs. We know this and apply this formula to the production of our super "Cell Protect" antioxidant supplement.
This is just a brief description of some facts that we have researched and uncovered throughout our antioxidant and immune system studies and hope you will choose "Cell Protect" as your daily antioxidant supplement. We offer you only the finest and purest extracts and strains in all of our supplements!
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